Can you use copper peptides with centella asiatica?
Reasoning: why this verdict
There is no known conflict between copper peptides and centella asiatica. Both are generally well tolerated.
Who should be careful: People with very sensitive skin, rosacea or eczema should patch test new products first.
How to use copper peptides and centella asiatica together
- Layer from thinnest to thickest texture.
- Finish with moisturizer, and sunscreen in the morning.
Products with copper peptides
The Ordinary Multi-Peptide + Copper Peptides 1% Serum
Picked for copper peptides
Copper tripeptide-1 is listed first, backed by several other peptides.
Buy on Amazon (opens in a new tab)About the ingredients
Copper Peptides
Mainly GHK-Cu, a copper-binding peptide studied for skin repair and remodeling.
Centella Asiatica (Cica)
A soothing plant extract (also called cica or gotu kola). Its compounds, such as madecassoside and asiaticoside, are studied for calming and repairing skin, mostly in lab work so far.
Related combinations
How Copper Peptides and centella asiatica each mix with other common actives.
FAQ
Do I need sunscreen with copper peptides and centella asiatica?
Yes. Daily broad-spectrum SPF 30+ is recommended with any active skincare routine.
Is this answer based on a study of copper peptides and centella asiatica together?
Evidence strength: Limited. Based on ingredient-level evidence and a conservative general rule for this ingredient class. Direct research on this pair is limited.
Which goes on first, copper peptides or centella asiatica?
Copper Peptides first, then centella asiatica. In general, apply thinner, watery textures before thicker creams.
Sources
Studies and reviews on these ingredients and, where available, on this specific combination. Numbers match the citation chips above.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108.
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci. 2018;19(7):1987.
- Najafi N, Maatouk H, Vardanyan KG, Vartanian KB, Agrawal DK. A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu in Topical Microneedle Delivery: A Case for Expanded Clinical Trials. Arch Intern Med Res. 2026;9(3):269-293.
- Miller TR, Wagner JD, Baack BR, Eisbach KJ. Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin. Arch Facial Plast Surg. 2006;8(4):252-9.
- Park KS. Pharmacological effects of Centella asiatica on skin diseases: evidence and possible mechanisms. Evid Based Complement Alternat Med. 2021;2021:5462633.
- Bylka W, et al. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013;30(1):46-49.