What can you mix with Adapalene?

A synthetic retinoid (Differin) for acne, available over the counter at 0.1% in the US. It is more chemically stable than tretinoin, including next to benzoyl peroxide.

• Retinol No, not together
• Vitamin C Yes, with timing
• Niacinamide Yes
• Tretinoin No, not together
• Salicylic Acid Yes, with timing
• Hyaluronic Acid Yes
• Glycolic Acid Yes, with timing
• Benzoyl Peroxide Yes
• Sunscreen Yes
• Azelaic Acid Yes, with care
• Lactic Acid Yes, with timing
• Ceramides Yes
• Copper Peptides Yes, with timing
• Bakuchiol Yes, with care
• AHA/BHA Peel No, not together
• Vitamin E Yes
• Ferulic Acid Yes

Sources

1. A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008;43(5).
2. Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.

Last reviewed: 2026-10-21. Not medical advice.