Adapalene + Lactic Acid (AHA)

Can you use Adapalene with Lactic Acid?

Yes, with timing

Yes, with timing. Use Adapalene and Lactic Acid on alternating nights rather than together.

Why

Both Adapalene and Lactic Acid speed up skin turnover. Layered together they commonly cause dryness, peeling and irritation, especially early on. Alternating gives you the benefits of both with less risk.

How to use them together

  1. Night A: Adapalene. Night B: Lactic Acid. Or use Lactic Acid in the morning and Adapalene at night if your skin tolerates it.
  2. Start slowly (2-3 nights a week each) and moisturize.
  3. Daily sunscreen is essential with both.

Who should be careful

Beginners, people with sensitive skin, rosacea or eczema, and anyone using prescription retinoids should ask their dermatologist before combining.

About the ingredients

Adapalene: A synthetic retinoid (Differin) for acne, available over the counter at 0.1% in the US. It is more chemically stable than tretinoin, including next to benzoyl peroxide.

Lactic Acid (AHA): A gentler alpha hydroxy acid with a larger molecule than glycolic acid. Exfoliates and helps hydrate. Like all AHAs, it can increase sun sensitivity.

FAQ

Can I use Adapalene and Lactic Acid together?

Yes, with timing. Use Adapalene and Lactic Acid on alternating nights rather than together.

Should I use Adapalene or Lactic Acid in the morning or at night?

Night A: Adapalene. Night B: Lactic Acid. Or use Lactic Acid in the morning and Adapalene at night if your skin tolerates it. Start slowly (2-3 nights a week each) and moisturize.

Who should be careful combining Adapalene and Lactic Acid?

Beginners, people with sensitive skin, rosacea or eczema, and anyone using prescription retinoids should ask their dermatologist before combining.

What if my skin gets irritated using Adapalene and Lactic Acid?

Stop the stronger active, keep a gentle cleanser, moisturizer and sunscreen, and reintroduce one product at a time once skin calms down. See a dermatologist if irritation persists.

Sources

Studies and reviews on these ingredients and, where available, on this specific combination.

  1. A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008;43(5).
  2. Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.
  3. Kornhauser A, Coelho SG, Hearing VJ. Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clin Cosmet Investig Dermatol. 2010;3:135-142.

Last reviewed: . Not medical advice.

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