Can you use Adapalene with Copper Peptides?
Yes, with timing. Use copper peptides and Adapalene at different times of day.
Why
There is little direct research on this combination. Many dermatologists suggest separating them out of caution, since both are active and stacking can irritate.
How to use them together
- AM: copper peptide serum, moisturizer, sunscreen.
- PM: Adapalene, moisturizer.
Who should be careful
Evidence is limited. Stop if you see irritation. People with very sensitive skin, rosacea or eczema should patch test new products first.
About the ingredients
Adapalene: A synthetic retinoid (Differin) for acne, available over the counter at 0.1% in the US. It is more chemically stable than tretinoin, including next to benzoyl peroxide.
Copper Peptides: Mainly GHK-Cu, a copper-binding peptide studied for skin repair and remodeling.
FAQ
Can I use Adapalene and Copper Peptides together?
Yes, with timing. Use copper peptides and Adapalene at different times of day.
Should I use Adapalene or Copper Peptides in the morning or at night?
AM: copper peptide serum, moisturizer, sunscreen. PM: Adapalene, moisturizer.
Who should be careful combining Adapalene and Copper Peptides?
Evidence is limited. Stop if you see irritation. People with very sensitive skin, rosacea or eczema should patch test new products first.
What if my skin gets irritated using Adapalene and Copper Peptides?
Stop the stronger active, keep a gentle cleanser, moisturizer and sunscreen, and reintroduce one product at a time once skin calms down. See a dermatologist if irritation persists.
Sources
Studies and reviews on these ingredients and, where available, on this specific combination.
- A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008;43(5).
- Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108.
Related combinations
- Can you use Retinol with Adapalene?
- Can you use Adapalene with Vitamin C?
- Can you use Adapalene with Niacinamide?
- Can you use Retinol with Copper Peptides?
- Can you use Tretinoin with Adapalene?
- Can you use Adapalene with Salicylic Acid?
- Can you use Adapalene with Hyaluronic Acid?
- Can you use Vitamin C with Copper Peptides?