Adapalene + Vitamin E

Can you use Adapalene with Vitamin E?

Yes

Yes. Vitamin E is a good partner for Adapalene.

Why

Vitamin E is gentle and can help offset the dryness and irritation retinoids cause. There is no known conflict.

How to use them together

  1. Apply Adapalene at night on clean, dry skin.
  2. Use Vitamin E before or after it (thinnest texture first), or as your moisturizer step.
  3. Sunscreen every morning.

Who should be careful

Retinoids are not recommended during pregnancy without medical advice. People with very sensitive skin, rosacea or eczema should patch test new products first.

About the ingredients

Adapalene: A synthetic retinoid (Differin) for acne, available over the counter at 0.1% in the US. It is more chemically stable than tretinoin, including next to benzoyl peroxide.

Vitamin E: A fat-soluble antioxidant (tocopherol) common in moisturizers and antioxidant serums. It can rarely cause contact allergy.

FAQ

Can I use Adapalene and Vitamin E together?

Yes. Vitamin E is a good partner for Adapalene.

Should I use Adapalene or Vitamin E in the morning or at night?

Apply Adapalene at night on clean, dry skin. Use Vitamin E before or after it (thinnest texture first), or as your moisturizer step.

Who should be careful combining Adapalene and Vitamin E?

Retinoids are not recommended during pregnancy without medical advice. People with very sensitive skin, rosacea or eczema should patch test new products first.

Do I need sunscreen with Adapalene and Vitamin E?

Yes. Daily broad-spectrum SPF 30+ is recommended with any active skincare routine.

Sources

Studies and reviews on these ingredients and, where available, on this specific combination.

  1. A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008;43(5).
  2. Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.
  3. Keen MA, Hassan I. Vitamin E in dermatology. Indian Dermatol Online J. 2016;7(4):311-315.

Last reviewed: . Not medical advice.

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