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Can you use Adapalene with Glycolic Acid?

Does It Mix engine · answer
Yes, with timing
Adapalene + Glycolic Acid

Yes, with timing. Use Adapalene and Glycolic Acid on alternating nights rather than together.1234

AdapaleneGlycolic Acid (AHA)
Evidence strength: Limited

Based on ingredient-level evidence and a conservative general rule for this ingredient class. Direct research on this pair is limited. How we grade

Best timePM
Apply orderSeparate routines (see steps)
SpacingDifferent time of day or night
Take care ifSensitive, dry or rosacea-prone skin
Reasoning: why this verdict

Both Adapalene and Glycolic Acid speed up skin turnover. Layered together they commonly cause dryness, peeling and irritation, especially early on. Alternating gives you the benefits of both with less risk.1234

Who should be careful: Beginners, people with sensitive skin, rosacea or eczema, and anyone using prescription retinoids should ask their dermatologist before combining.

How to use Adapalene and Glycolic Acid together

  1. Night A: Adapalene. Night B: Glycolic Acid. Or use Glycolic Acid in the morning and Adapalene at night if your skin tolerates it.
  2. Start slowly (2-3 nights a week each) and moisturize.
  3. Daily sunscreen is essential with both.

About the ingredients

Retinoid

Adapalene

A synthetic retinoid (Differin) for acne, available over the counter at 0.1% in the US. It is more chemically stable than tretinoin, including next to benzoyl peroxide.

Exfoliating acid

Glycolic Acid (AHA)

The smallest alpha hydroxy acid. A chemical exfoliant for texture and dullness. It can increase sun sensitivity.

How they each mix with other actives

IngredientWith AdapaleneWith Glycolic Acid
RetinolNo, not togetherYes, with timing
Vitamin CYes, with timingYes, with timing
NiacinamideYesYes
TretinoinNo, not togetherYes, with timing
Salicylic AcidYes, with timingYes, with care
Hyaluronic AcidYesYes
Benzoyl PeroxideYesYes, with timing
SunscreenYesYes
Azelaic AcidYes, with careYes, with care
Lactic AcidYes, with timingYes, with care

FAQ

Can I use Adapalene and Glycolic Acid together?

Yes, with timing. Use Adapalene and Glycolic Acid on alternating nights rather than together.

Should I use Adapalene or Glycolic Acid in the morning or at night?

Night A: Adapalene. Night B: Glycolic Acid. Or use Glycolic Acid in the morning and Adapalene at night if your skin tolerates it. Start slowly (2-3 nights a week each) and moisturize.

Who should be careful combining Adapalene and Glycolic Acid?

Beginners, people with sensitive skin, rosacea or eczema, and anyone using prescription retinoids should ask their dermatologist before combining.

What if my skin gets irritated using Adapalene and Glycolic Acid?

Stop the stronger active, keep a gentle cleanser, moisturizer and sunscreen, and reintroduce one product at a time once skin calms down. See a dermatologist if irritation persists.

Sources

Studies and reviews on these ingredients and, where available, on this specific combination. Numbers match the citation chips above.

  1. A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008;43(5).
  2. Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.
  3. Kornhauser A, Coelho SG, Hearing VJ. Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clin Cosmet Investig Dermatol. 2010;3:135-142.
  4. Kaidbey K, et al. Topical glycolic acid enhances photodamage by ultraviolet light. Photodermatol Photoimmunol Photomed. 2003;19(1):21-27.
DM
Reviewed by the Does It Mix editorial team

Last reviewed . Verdicts come from the Does It Mix engine, a transparent rule set we wrote over the cited research, then edited by hand for the most-asked pairs. Read our methodology. Not medical advice.

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