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Can you use Adapalene with Azelaic Acid?

Does It Mix engine · answer
Yes, with care
Adapalene + Azelaic Acid

Yes, with care. Adapalene and azelaic acid can be used together, often at different times.1234

AdapaleneAzelaic Acid
Evidence strength: Limited

Based on ingredient-level evidence and a conservative general rule for this ingredient class. Direct research on this pair is limited. How we grade

Best timeAdapalene: PM · Azelaic Acid: AM or PM
Apply orderSeparate routines (see steps)
SpacingIntroduce one at a time
Take care ifSensitive, dry or rosacea-prone skin
Reasoning: why this verdict

Azelaic acid and retinoids are both used for acne and pigmentation, and dermatologists often combine them. Both can tingle or dry the skin, so build up slowly.1234

Who should be careful: Start one at a time. Ask a dermatologist if you use prescription strengths.

How to use Adapalene and Azelaic Acid together

  1. Easiest: azelaic acid in the morning, retinoid at night.
  2. Moisturize and wear daily sunscreen.

About the ingredients

Retinoid

Adapalene

A synthetic retinoid (Differin) for acne, available over the counter at 0.1% in the US. It is more chemically stable than tretinoin, including next to benzoyl peroxide.

Multi-purpose acid

Azelaic Acid

A multitasking acid for acne, rosacea and hyperpigmentation. Usually well tolerated, though it can tingle at first.

How they each mix with other actives

IngredientWith AdapaleneWith Azelaic Acid
RetinolNo, not togetherYes, with care
Vitamin CYes, with timingYes, with care
NiacinamideYesYes
TretinoinNo, not togetherYes, with care
Salicylic AcidYes, with timingYes, with care
Hyaluronic AcidYesYes
Glycolic AcidYes, with timingYes, with care
Benzoyl PeroxideYesYes, with timing
SunscreenYesYes
Lactic AcidYes, with timingYes, with care

FAQ

Can I use Adapalene and Azelaic Acid together?

Yes, with care. Adapalene and azelaic acid can be used together, often at different times.

Should I use Adapalene or Azelaic Acid in the morning or at night?

Easiest: azelaic acid in the morning, retinoid at night. Moisturize and wear daily sunscreen.

Who should be careful combining Adapalene and Azelaic Acid?

Start one at a time. Ask a dermatologist if you use prescription strengths.

What if my skin gets irritated using Adapalene and Azelaic Acid?

Stop the stronger active, keep a gentle cleanser, moisturizer and sunscreen, and reintroduce one product at a time once skin calms down. See a dermatologist if irritation persists.

Sources

Studies and reviews on these ingredients and, where available, on this specific combination. Numbers match the citation chips above.

  1. A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008;43(5).
  2. Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.
  3. The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications. Postepy Dermatol Alergol. 2023.
  4. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. Cochrane Database Syst Rev. 2020;5:CD011368.
DM
Reviewed by the Does It Mix editorial team

Last reviewed . Verdicts come from the Does It Mix engine, a transparent rule set we wrote over the cited research, then edited by hand for the most-asked pairs. Read our methodology. Not medical advice.

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