How long should you wait between Tretinoin and Glycolic Acid?
Does It Mix engine · wait time
Waiting a few minutes isn't the fix here: use Tretinoin and Glycolic Acid in different routines (morning vs night) or on different nights.
The routine
- Night A: Tretinoin. Night B: Glycolic Acid. Or use Glycolic Acid in the morning and Tretinoin at night if your skin tolerates it.
- Start slowly (2-3 nights a week each) and moisturize.
- Daily sunscreen is essential with both.
Why: full Tretinoin + Glycolic Acid answer and sources.
FAQ
Does waiting 20 or 30 minutes between products help?
We haven't found good evidence that a set wait of many minutes changes how most skincare works. The practical reason to pause is letting each layer absorb so the next one doesn't pill or sting.
Sources
- Zaenglein AL, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-973.
- Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.
- Kornhauser A, Coelho SG, Hearing VJ. Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clin Cosmet Investig Dermatol. 2010;3:135-142.
- Kaidbey K, et al. Topical glycolic acid enhances photodamage by ultraviolet light. Photodermatol Photoimmunol Photomed. 2003;19(1):21-27.