How long should you wait between Retinol and Tretinoin?
Does It Mix engine · wait time
No wait time makes these OK together. Don't use Retinol and Tretinoin in the same routine.
The routine
- Pick one retinoid. If a dermatologist prescribed one, follow their plan.
- If switching from one to the other, stop the first before starting the second.
Why: full Retinol + Tretinoin answer and sources.
FAQ
Does waiting 20 or 30 minutes between products help?
We haven't found good evidence that a set wait of many minutes changes how most skincare works. The practical reason to pause is letting each layer absorb so the next one doesn't pill or sting.
Sources
- Kafi R, et al. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007;143(5):606-612.
- Zaenglein AL, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-973.
- Martin B, et al. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139 Suppl 52:8-11.