How long should you wait between Vitamin C and Azelaic Acid?
Does It Mix engine · wait time
When you're starting out, don't layer them back to back: use Vitamin C and Azelaic Acid at different times of day or on alternate days, then layer only if your skin stays calm.
The routine
- Vitamin C in the morning, azelaic acid at night, or alternate.
Why: full Vitamin C + Azelaic Acid answer and sources.
FAQ
Does waiting 20 or 30 minutes between products help?
We haven't found good evidence that a set wait of many minutes changes how most skincare works. The practical reason to pause is letting each layer absorb so the next one doesn't pill or sting.
Sources
- Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients. 2017;9(8):866.
- Al-Niaimi F, Chiam NYZ. Topical vitamin C and the skin: mechanisms of action and clinical applications. J Clin Aesthet Dermatol. 2017;10(7):14-17.
- The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications. Postepy Dermatol Alergol. 2023.
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. Cochrane Database Syst Rev. 2020;5:CD011368.